Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

Har Lal Singh,A Mukherjee,Jangbhadur Singh

doi:10.1155/2013/425832

Har Lal Singh, A Mukherjee + Show 1 more

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https://doi.org/10.1155/2013/425832

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Abstract

The present work stems from our interest in the synthesis, characterization, and antibacterial evaluation of organosilicon(IV) complexes of a class of amino-acid-based Schiff base which have been prepared by the interaction of ethoxytrimethylsilane with the Schiff bases (N OH) in 1 : 1 molar ratio. These complexes have been characterized by elemental analysis, molar conductance, and spectroscopic studies including electronic IR and NMR (1H, 13C, and 29Si) spectroscopy. The analytical and spectral data suggest trigonal bipyramidal geometry around the silicon atom in the resulting complexes. The ligands and their organosilicon complexes have also been evaluated for in vitro antimicrobial activity against bacteria (Bacillus cereus, Nocardia spp., E. aerogenes, Escherichia coli, Klebsiella spp., and Staphylococcus spp.). The complexes were found to be more potent as compared to the ligands.

Highlights

In the last decade, coordination and organometallic compounds of biologically active ligands [1,2,3] have received much attention
Synthesized compounds were screened for their antibacterial activity against Bacillus cereus, Nocardia spp., E. aerogenes, Escherichia coli, Klebsiella spp., and Staphylococcus spp. at the concentrations of 100 μg/mL by the agar well-diffusion method [29]
On the basis of zone of inhibition produced against the test bacterium, compound 3 was found to be most effective against Bacillus cereus, Nocardia spp., Staphylococcus spp., E. coli, Klebsiella spp., and E. aerogenes with zone of inhibition of 12.6 mm, 12.7 mm, 12.9 mm, 9.5 mm, 9.9 mm, and 8.7 mm, respectively (Table 5)

Summary

Introduction

Coordination and organometallic compounds of biologically active ligands [1,2,3] have received much attention. It is notable that the biological activity of Schiff bases was significantly enhanced on chelation. Schiff base complexes [4,5,6,7] have found antibacterial, antifungal, anticancer, tuberculostatic, and herbicidal activities [8,9,10,11,12]. Heteronuclear Schiff base complexes have found applications as magnetic materials, catalysts and in the field of bioengineering [17, 18]. Organosilicon compounds of nitrogen and sulphur containing ligands are well known for their anticarcinogenic, antibacterial, tuberculostatic, antifungal, insecticidal, and acaricidal activities [19,20,21,22]. The characterization of the complexes was realised by elemental analysis and spectroscopic (UV, IR, 1H, 13C, and 29Si NMR) studies Their antibacterial activities were screened against various bacteria

Experiment

Results and Discussion

Conclusions