Synthesis, solid-state nuclear magnetic resonance characterization and chromatographic evaluation of a diphenylphosphine-octadecylsilane hybrid bonded phase

Abstract

Mixed-mode bonded phases consisting of diphenylphosphinoethylsilane concurrently immobilized with octadecyldimethylsilane were synthesized. Elemental analysis and solid-state nuclear magnetic resonance (NMR) spectroscopy were employed in order to characterize the surface structure. Using the techniques of cross-polarization/magic angle spinning, 13C, 31P and 29Si NMR spectra were obtained with a resolution approaching that usually obtained for liquids. The novel diphenylphosphine-octadecylsilane (DPP-ODS) bonded phase was then evaluated for its chromatographic potential in the separation of a series of aromatic compounds. Preliminary results indicate that the column prepared from this material is a ”hybrid“, exhibiting reversed-phase character under hydroorganic eluent conditions, and polar character when the eluent is non-polar.