Abstract
This review discusses recent progress in the synthesis of inositol phosphates and their analogues. Most of the research published prior to 1992 has been extensively reviewed (Potter and Nahorski, 1992; Potter, 1990; Billington, 1989), probably most completely in the book by Billington (1993). Therefore, mainly findings published since then and some of the most important earlier results are covered by this chapter. A brief discussion of the biochemistry of intracellular inositol phosphates in respect to cell signaling is presented, followed by some of the most crucial stereochemical aspects of inositol phosphates. The synthesis of naturally occurring myo-inositol phosphates and their synthetic derivatives is covered. In particular, the efforts to find agonists and antagonists of the most prominent inositol phosphate, myo-inositol-l,4,5-trisphosphate [Ins(1,4,5)P3], are summarized, including some of their biochemical properties. Finally, some of the most widely used techniques for separation and identification of inositol phosphates are presented.
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