Abstract
In this paper, gadolinium orthophosphate (GdPO4) hollow spheres with good luminescent properties, better drug loading and sustainable release have been synthesized by a template-oriented route. The precursor with core–shell structure was facilely prepared by a homogeneous precipitation and followed solvothermal method with 3-aminophenol-formaldehyde (APF) resin spheres as template. Subsequently, the APF template was eliminated and the crystalline GdPO4 hollow spheres were obtained after an annealing process. The structure, morphology, and formation process of the as-obtained GdPO4 hollow spheres have been investigated in detail. It is worth noting that lanthanide activator ions doped GdPO4 can perform optical and MRI dual-mode imaging functions. Moreover, the as-obtained GdPO4 hollow spheres exhibit good drug loading and sustained drug release behaviors. The unique hollow structure, dual-mode optical and MRI imaging capabilities, and good drug loading/release patterns enable the as-synthesized products to have enormous potential in bioimaging, drug delivery, and disease diagnosis.
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