Abstract
A new anionic dendrimer (D1) has been synthesized and characterized by modification of a poly(amidoamine) (PAMAM) dendrimer with 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3 H)-yl)propanoic acid (NI1). Its photophysical characteristics have been investigated in organic solvents of different polarity and a positive solvatochromism has been observed. The effect of the pH medium on the fluorescence intensity has been investigated and it has been shown that in the highly alkaline medium the dendrimer emits intense fluorescence. The dendrimer and its monomeric structural analogue have been loaded on a cotton fabric and the release of substances from the surface of the cotton fabric has been investigated. The compounds have been screened for antimicrobial and cytotoxic activities. They have been found more active against Gram-positive bacteria. The dendrimer exhibits slightly lower activity than the monomeric analogue, but is found to be significantly less cytotoxic. The deposited on cotton fabric D1 prevents the formation of bacterial biofilm on the fabric surface.
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