Abstract
Reactions of hydrochlorides of glycine, alanine, phenylalanine, L-isolcucinc, and L-valine esters with aromatic and heteroaromatic carboxamides afforded hydrochlorides of the correspondingN-(amidomethyl)-α-amino acid esters.N-(Phthalimidomethyl)-α-amino acid esters were obtained by reactions of α-amino acid esters containing free amino groups with formaldehyde and phthalimide, The1H NMR studies demonstrated that the chiral centers of α-amino acids may be retained in the course of condensation. Reactions of the Mannish bases obtained and their hydrochlorides with acetic anhydride and tosyl chloride afforded the correspondingN-aryl andN-sulfonyl derivatives.
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