Abstract
( Z)-2-(2-Acetyl-2 H-isoquinolin-1-ylidene)acetamides have been synthesized from 2-vinylbenzonitrile derivatives in three steps. The key step involves the iodine-mediated 6- ENDO cyclization of ( Z)-3-acetylamino-3-(2-vinylphenyl)propenamides, which are prepared by the coupling of 2-vinylbenzonitriles with magnesium enolates of tertiary amides followed by N-acetylation.
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