Abstract
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.
Highlights
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation
Molecular weight was studied as a function of time for the product dissolved in DMSO and in water
We recently found that anticancer activity is brought about by the intact polymer and not through polymer degradation [31]
Summary
Polymer solubility is both difficult and low compared with the solubility of smaller molecules, and is limited by the amount of suitable solvent, extent of solubility, and rapidness of solubility. Over 50 years ago, Bailar, one of the pioneers of inorganic chemistry, described some problems associated with the solubility of metal-containing polymers [1]. Employed solvents should not form strong complexes with the metal or chelating agent or they will be incorporated into the polymer structure and/or prevent a reaction from occurring. These problems are present with all metal-containing polymers. Why is it important to have water solubility for polymers that are considered for use as drugs?. Recent activities involve the use of poly(ethylene oxide), PEG, to achieve water solubility for metal-containing polymers. The average is 396/2, or approximately 200, which is what this particular product is sold as
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