Abstract
New water soluble fulleropyrrolidines endowed with biologically active arylpiperazines have been synthesized by 1,3-dipolar cycloaddition of in situ generated azomethyne ylides to C 60. The substitution pattern on the pyrrolidine and piperazine rings ensures their solubility in a H 2O/DMSO (9:1) solvents mixture. The mass spectrometry study reveals a different fragmentation pathway for the fulleropyrrolidines depending upon the substituent on the pyrrolidine nitrogen atom, affording in all cases to differently substituted methanofullerenes. Preliminary biological tests reveal a moderate activity in vitro experiments.
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