Abstract
The reaction of cyanocobalamin (CNCbl) with sodium hydroxymethanesulfinate (HMS) was studied over a wide range of pH (4–11) under aerobic conditions. CNCbl is destroyed in the presence of HMS in aqueous solution to form uncolored substances. The accumulation of stable yellow corrinoids (SYCs) preceded these changes at pH [Formula: see text] 8. The major stable yellow corrinoid is (15R)-Co[Formula: see text], Coß — dicyano-13-dehydro-15-hydro-l5-hydroxycob(III)alamin. The yield of this SYC is 25%, and the stability of this compound decreases significantly with increasing concentrations of HMS, pH and temperature.
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