Abstract
A method where an allyl alcohol is formed from a Tsuji-Trost allylation between a vinyl epoxide and an acyl containing nucleophile is described. Subsequently, a retro-Claisen condensation is utilized as a means of through-space anion relay. The anion relay results in the formation of a reactive carbanion and simultaneously activates an allylic alcohol toward intramolecular Tsuji-Trost cyclopropanation. Hence, in one pot, Tsuji-Trost allylation, retro-Claisen activation, and Tsuji-Trost cyclopropanation are combined to access synthetically useful vinyl cyclopropanes from vinyl epoxides using a mild and operationally simple procedure.
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