Abstract
By attaching maleimide groups to anticancer drugs are obtained which bind selectively to thiolated carrier proteins. Two maleimide ester derivatives of platinum(II) complexes which consist of an active cis-configurated platinum(II) moiety and a maleimide group capable of binding to thiolated carriers were prepared, i.e. N-( O-(3-maleimidobenzoyl)-2-hydrpxyethyl)-1,2-diaminoethanedichloropl atinum(II) ( 7) and N-( O-(2-maleimidophenyl)acetyl)-2-hydroxyethyl)-1,2-diaminoethanedichloroplatinum(II) ( 8), 7, and 8 were characterized through 1H and 11C NMR spectroscopy, IR spectroscopy, elemental analysis and mass spectrometry (FAB).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
