Abstract
Abstract[5′‐3H]‐5‐Chloro‐2′,3′‐diodeoxy‐3′‐fluorouridine (1; R = [3H]) was prepared at a specific activity of 10.2 Ci/mmol suitable for development of a radioimmunoassay procedure. The synthetic sequence employed controlled oxidation of unlabelled 1 to the 5′‐aldehyde (2), isolation as the imidazolidine adduct (3), regeneration of the free aldehyde, reduction with [3H]NaBH4, and purification by preparative TLC. The radiochemical purity was 98.0%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Labelled Compounds and Radiopharmaceuticals
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
