Abstract
The title myo-[1-3H]-Inositol derivative was synthesized and characterized by tritium-N.M.R. The unlabelled compound proved a potent inhibitor of the cellular key enzyme phosphatidylinositol-specific phospholipase-C (PI-PLC) involved in the production of intracellular second messengers and its tritium derivative was necessary in order to fully understand the mechanism of inhibition. © 1997 John Wiley & Sons, Ltd.
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