Synthesis of trisubstituted furans via Ag-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines

Abstract

A silver(I)-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines is described to synthesize trisubstituted furans in moderate to good yields. Tertiary amine is also efficient in this reaction. This transformation proceeds smoothly with the formation of C–N or C–C bonds in one-pot with good functional group tolerance under mild conditions.