Abstract
Tremulenediol A and Tremulenolide A were isolated from the fungal pathogen Phellinus tremulae and belong to the tremulane class of sesquiterpenes. This first enantioselective synthesis of both natural products employs three efficient transition-metal-catalyzed reactions: Rh-catalyzed asymmetric cyclopropanation, Pd-catalyzed allylic alkylation and Rh-catalyzed [5+2] cycloaddition.
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