Abstract
In view of the fact that a large number of derivatives of benzoxazole have been found toexhibit a wide variety of antimicrobial activities. Heterocyclic compounds play an importantrole in medicinal chemistry and exhibit wide range of biological activities in pharmaceuticalchemistry. Complexes of 2-aminobenzoxazole (L) with chloride of iron (II), was synthesized.The molar ratio metal: ligand in the reaction of the complex formation was 1:2. It should benoticed, that the reaction of all the metal salts yielded bis (ligand) complex of the generalformula M (L) 2(CL) 2. The complex was characterized by elemental analysis, melting point,FT-IR, 1H NMR, spectral data. The antifungal activity against different fungai, A.niger,A.flavus, Fusarium oxysporum, paecilomyces variotii, C.albicans.
Highlights
The derivative of benzoxazole is 2-amino benzoxazole is present in compounds involved in research aimed at evaluating new metal ion complex that possess interesting biological activities like antimicrobial activities
The synthesized compounds were screened for antimicrobial activity by zone of inhibition method
The IR spectrum of metal complex has been recorded in table 2
Summary
The derivative of benzoxazole is 2-amino benzoxazole is present in compounds involved in research aimed at evaluating new metal ion complex that possess interesting biological activities like antimicrobial activities. Benzoxazoles derivative have been reported to show a broad range of biological activities. Notable among these are antiviral, antifungal and antibacterial activities, etc. The approach to practice medicinal chemistry has developed from an empirical one involving organic synthesis of new compound, based largely on modification of structures of known activity[1]. According to Manfred Wolf, present development of medicinal chemistry has resistance, stating that “underlying the new age in foundation that includes explosive development of molecular biology since 1960, the advances in physical chemistry and physical organic chemistry has made possible by high speed computers and new powerful analytical methods. Cyclic anhydrates, cyclic imides, cyclic acetals of dihydroxy alcohols, the solvents, dioxanes and tetrahydrofuran, in all of these, the chemistry is
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