Synthesis of thiophene-substituted ketones via Manganese-Catalyzed Dehydrogenative Coupling Reaction.

Abstract

This study reports an efficient and green one-step method for synthesizing thiophene-substituted ketones from 2-thiophenemethanoland ketonesvia dehydrogenative coupling using manganese complexes as catalysts.The manganese complex demonstrated a broad applicability under mild conditions and extended the range of usable substrates. Utilizing this strategy, we carried out an efficient and diverse reaction of ketones with 2-thiophenemethanol, and successfully synthesized a series of thiophene-substituted saturated ketonesand α,β-unsaturated ketones in good isolated yields.