Abstract
In this paper the preparations of the taxane analogue PNU-105298 (1), labelled with deuterium and with carbon-14 are described. A three-step sequence starting from the commercially available (tert-[ 2 H 9 ]butyl)amine afforded the deuterium specifically labelled final compound [ 2 H 9 ]PNU-105298 (1a). The preparation of the carbon-14 labelled final compound[ 14 C]]PNU-105298 (1b) was carried out in a similar fashion yielding the radiochemically pure product with a specific activity of 2.15 GBq/mmol.
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