Abstract
The first synthesis of the tricyclic pyrrolo[2,3- i]isoquinoline substructure of manzamines A, B ,E and F is described. Reductive alkylation of benzoic acid followed by a 3-aza-6-heptenyl radical cyclization gave octahydro-isoquinoline 9. An electrophile initiated cyclization was used to complete construction of the title ring system.
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