Abstract
Abstract The synthesis of the pyrido[4,3-d]pyrimidine congeners (7 and 8) of inosine and adenosine from the known precursor 3-dimethylamino-2-(2,3-0-isopropylidene-5–0-trityl-D-ribofuranosyl)acrylonitrile (10) is described. The synthetic sequence involves a modified Thorpe-Ziegler annulation to a 4-amino-3-cyanotetrahydropyridine derivative (22) followed by aromatization to an α, β mixture of the desired 5-ribosyl-4-amino-3-cyanopyridine intermediates (25 and 26). Further annulation to the pyrido[4,3-d]pyrimidine ring system and simultaneous detritylation and deisopropylidenation completes the synthesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
