Abstract
The regular polypeptides (Ala-Orn-Orn)n and (Ala-Orn-Lys)n have been synthesized by the polycondensation of the 2,4,5-trichlorophenyl esters of the corresponding tripeptides, which were obtained by the mixed-anhydride method. Benzyloxycarbonyl and tert-butoxycarbonyl groups were used for blocking the amino groups. The polycondensation was performed in dimethylformamide in the presence of triethylamine at room temperature for 6 days. The benzyloxycarbonyl groups were eliminated from the side chains of the polypeptides with 35% hydrogen bromide in glacial acetic acid. It has been shown by the method of circular dichroism that the adoption of the conformation of an extended left-hand helix is characteristic for both polypeptides, which model the terminal sections of histones.
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