Abstract
The nonatriacontapeptide corresponding to the entrie amino acid sequence of dogfish adrenocorticotropic hormone was synthesized by successive condensations of three peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-NHNH2 and Z-(1-10)-OH, with H-(20-39)-OBzl, a synthetic intermediate of dogfish corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the in vivo steroidogenetic activity of 21.3 IU/mg.
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