Abstract
The main encephalitogenic determinant of bovine myelin basic protein (MBP 114-122) has been synthesized through fragment condensation of tetrapeptide, Boc-Phe-Ser-Trp-Gly-OH, and penta-peptide, H-Ala- Glu(OBzl)-Gly-Gln-Lys(Nε-Cbz)-Obzl. It was observed that the benzyl ether protecting group of the serine side chain was not removed during catalytic hydrogenation (Pd/C-H2) of the tetrapeptide, Boc-Phe- Ser(OBzl)-Trp-Gly-OBzl. 13C N.M.R. spectra of some other intermediates are discussed.
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