Abstract
The conjugate with human serum albumin (HSA) of the S-linked thioanalogue of the branched tetrasaccharide repeating unit of the polysaccharide, schizophyllan, was synthesized from 1,2,4,6-tetra- O-acetyl-3- S-[2,4-di- O-acetyl-3,6-di- S-(2,3,4,6-tetra- O-acetyl-β- d-glucopyranosyl)-3,6-dithio-β- d-glucopyranosyl]-3-thio-β- d-glucopyranose [M.O. Contour-Galcera et al., Carbohydr. Res., 281 (1996) 119–128] in five steps, and its potential immunomodulatory activity was evaluated in human blood mononuclear cells. The protein glycoconjugate did not effect proliferation or production of IL-4, IL-5 and IFN-g in a significant way.
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