Abstract
AbstractThe glycopentapeptide H‐(GlcNAcβ1‐)Asn‐Glu‐Thr‐Ile‐Val‐OH (10) representing the partial sequence A80–A84 of human fibroblast interferon was synthesized using the newly developed allyl‐ester protection of carboxy functions. The allyl esters, which are stable to acids and to bases, can be cleaved under very mild, neutral conditions using tris(triphenylphosphine)rhodium(I) chloride or tetrakis(triphenylphosphine)palladium(0) as a catalyst. This synthetic method opens up a preparative route to glycopeptide model structures of glycoproteins of high biological interest.
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