Abstract
Abstract Stereoselective synthesis of the C9-C22 fragment of pentamycin from the bis-Weinreb amide of d -tartaric acid was accomplished in 12 steps (14% yield). Key reactions in the synthesis include Ley’s dithiaketalization, Narasaka stereoselective reduction of the β-hydroxy ketone and Wittig reaction with a vinylogous phosphonate.
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