Abstract
In this study, Fe3O4/ZnO/chitosan magnetic nanoparticles were synthesized by an ultrasound-assisted coprecipitation method. The magnetic nanoparticles were characterized by XRD, FT-IR, FESEM, and VSM techniques. The effects of ultrasonication time and content of chitosan on crystal size and lattice parameters of the nanoparticles were also studied via XRD spectra. FESEM measurements revealed that the coating consists of Fe3O4/ZnO nanoparticles of 15-20 nm in diameter homogeneously dispersed on the surface of chitosan substance. The VSM measurements at room temperature showed that the Fe3O4/ZnO/chitosan nanoparticles had superparamagnetic properties. These results indicated that ultrasonication time and chitosan content had a significant effect on the characteristics of nanoparticles. The antibacterial activities of the Fe3O4/ZnO/chitosan were tested against both gram-positive Saccharomyces cerevisiae and Bacillus subtilis and gram-negative E. coli bacteria using a disk diffusion method.
Highlights
Iron oxide (Fe3O4) nanoparticles (ION) have attracted the attention of scientists all over the world due to its various applications, in biomaterial engineering, such as MRI contrast agent, hyperthermia treatment, and drug delivery [1,2,3,4,5]
The work performed by Vardikar et al revealed that the kaolin-chitosan-TiO2 ternary nanocomposites synthesized by a sonochemical route had many advantages for dye adsorption over those prepared by a conventional method [27]
Once the ammonia solution was added to the reaction solutions, it produced OH- anions reacting with Fe2+ and Fe3+ cations to form Fe3O4 nanoparticles
Summary
Iron oxide (Fe3O4) nanoparticles (ION) have attracted the attention of scientists all over the world due to its various applications, in biomaterial engineering, such as MRI contrast agent, hyperthermia treatment, and drug delivery [1,2,3,4,5]. The combination of chitosan and inorganic nanoparticles like ZnO would form antibacterial materials with multifunctional properties [20]. The ultrasonicassisted method exhibited its effectiveness in the preparation of ternary chitosan/ZnO/TiO2 nanocomposite for crystal violet (CV) dye adsorption reported by Bhanvasea et al [26]. The work performed by Vardikar et al revealed that the kaolin-chitosan-TiO2 ternary nanocomposites synthesized by a sonochemical route had many advantages for dye adsorption over those prepared by a conventional method [27]. To the best of our knowledge, there is a lack of reports on the synthesis of ternary Fe3O4/ZnO/chitosan nanoparticles via a coprecipitation ultrasonication method for antibacterial and antifungal application. In this research, we synthesized Fe3O4/ZnO/chitosan nanoparticles using a coprecipitation-ultrasonication method. The effects of chitosan concentration, magnetic properties, and antibacterial activity were investigated
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