Abstract
Tamiflu is a potent neuramidase inhibitor which is used for the treatment of the avian H5N1 virus. Key steps in the 15-step asymmetric synthesis depicted are (a) a catalytic asymmetric cleavage of meso-aziridine A with TMSN3 and (b) a diastereoselective cyanophosphorylation of the enone E.
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