Abstract
The sulfur-selenium doped carbon quantum dots (S,Se-CQDs) were synthesized by one-step through hydrothermal method in this study, which have high fluorescence quantum yield (43%) and advanced ability to scavenge reactive oxygen species (ROS). They were characterized by transmission electron microscope (TEM), nuclear magnetic resonance (NMR), X-ray photoelectron spectroscopy (XPS), fourier transform infrared spectroscopy (FTIR). The results showed that the clearance rate of free radical reached to 40% with 200 μg/mL of S,Se-CQDs. The antioxidant activity of S,Se-CQDs is related to -SH and Se-SH on carbon quantum dots. S,Se-CQDs were able to access to cells which is beneficial to enhance the removal efficiency to ROS. In the biocompatibility experiment, the cell survival rate exceeded 95%, there was little effect on hatching rate, survival rate and heart rate of zebrafish which demonstrated that S,Se-CQDs have an excellent biocompatibility. It prompts that S,Se-CQDs will has proud application prospects in the field of biomedicine.
Highlights
CQDs, as a new member of the carbon material family, has been concerned widely due to their excellent optical and chemical properties[5,6]
The fluorescence quantum yield of S,Se-CQDs reach to 43%, measuring fluorescence intensity at different excitation wavelengths
S,Se-CQDs were characterized by nuclear magnetic resonance (NMR) (Fig. 2)
Summary
CQDs, as a new member of the carbon material family, has been concerned widely due to their excellent optical and chemical properties[5,6]. The fluorescence quantum yield of S,Se-CQDs reach to 43%, measuring fluorescence intensity at different excitation wavelengths. Hydroxyl radical reacts with salicylic acid to form 2,3-dihydroxybenzoic acid with special absorption at 510 nm UV24.The results (Fig. 5b) showed the ability of S,Se-CQDs to clear ·OH reached to 15%, because the sulfhydryl on the surface of S,Se-CQDs can provide H to react with ·OH which endue S,Se-CQDs a certain ability to scavenge ·OH25.
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