Synthesis of Sulfonyl Quinone Derivatives by Rh-Catalyzed Sulfonylation of Quinones

Abstract

The rhodium-catalyzed sulfonylation reaction of quinones with sulfonyl chloride compounds was developed, which provides an efficient and mild method of the synthesis of biologically active sulfonyl quinones with high yields. This methodology is also efficient for the coupling of naphthoquinone with sulfonyl chlorides. The possible reaction mechanism was also proposed.