Synthesis of α-sulfonyl ketoximes through a salicylic acid-catalyzed four-component reaction involving radical sulfonylation followed by arylsulfonylation and oximation

Abstract

A four-component reaction of styrene derivatives, anilines, t-butyl nitrite, and DABSO was used to prepare α-sulfonyl ketoximes. The reaction was realized through a salicylic acid-catalyzed aryl radial formation and ensuing sulfonylation by DABSO, followed by arylsulfonylation and oximation of styrenes. Under the optimized conditions, the title compounds were obtained in good yields within 30 min.