Synthesis of sulfonimide-based branched arylsulfonyl chlorides

Abstract

A four-step synthesis of two branched arylsulfonyl chlorides bearing a sulfonimide branching point is described. The protocol consists of the nucleophilic substitution of a nitro group or a halogen in the corresponding nitro aromatic compounds with benzyl mercaptide and reduction of the remaining nitro group to the amino group. The latter was persulfonylated with 4-toluene sulfonyl chloride and, finally, the benzylsulfide group was converted into a sulfonyl chloride moiety.