Abstract
AbstractTropones are commercially available and extremely valuable non‐benzenoid aromatic compounds. Tropone and its derivatives are very important building blocks that are immensely used in synthetic organic chemistry and other mechanistic studies. In the broad realm of cycloaddition reactions, tropones behave as versatile cycloaddition partners. In these reactions, they act as 4π, 6π or, 8π synthons. The cycloaddition products derived from tropone play a noticeable role in the synthesis of bioactive molecules. Tropone is a veritable example as a precursor for the synthesis of natural products.. Tropones are one of the major scaffolds in pharmaceutical chemistry. This review is focused on a few protocols for the synthesis of substituted tropones, tropolones and the racemic, asymmetric reactions of tropones that occurred in the last decade (2012–2021).
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