Synthesis of substituted styrenes and 3-vinylphenols using ruthenium-catalyzed ring-closing enyne metathesis.

Abstract

The synthesis of substituted styrenes 3 and 3-vinylphenols 9 was achieved by ring-closing enyne metathesis (RCEM)/dehydration of 7 and RCEM/tautomerization of 8, respectively. Those methods provide selective access to unique aromatic compounds and solve the problem of regioisomer formation.