Synthesis of β-Substituted Calix[4]Pyrroles and Their Salts

Abstract

Calix[4]pyrroles are heterocalixarene analogs that are capable of binding to anionic and neutral substrates, known for a long time, but the anion binding properties have recently been discovered. Calix[4]pyrroles are easy to synthesize and add functional groups. Bu nedenle bircok amac icin kullanilabilirler. Therefore, they can be used for many purposes. They can be used, in chemistry, as a separating medium for anionic and neutral species, and as a useful precursor for specific calixpyridinopyrroles and calixpyridines. In some special studies, under potential interface conditions, calix[4]pyrroles have been synthesized in order to reverse the Hoffmeister tendency, that is, to use as anion extractants. This anionic extraction scheme can be used in known some environmental applications like nuclear industry, reducing surface aqueous eutrophication, etc. Besides, calix[4]pyrrole derivatives, being highly soluble in organic solvents, may be helpful in the therapy of cystic fibrosis as continuous membrane chloride anion carriers. In this study, it was aimed to synthesize calix[4]pyrrole monocarboxylic acids as derivatives of calix[4]pyrrole and investigation of their tetrabutylammonium salts. Calix[4]pyrrole monocarboxylic acid, having an acidic functional group, and tetrabutylammonium cation were reacted to obtain the intermolecular oligomeric salt structures along with investigation of their properties.