Abstract
AbstractIn the catalytic addition of thiols to 16‐dehydropregnenolone fourteen thioethers were prepared via thiol‐Michael addition reaction in the presence of different aliphatic and aromatic thiols as reagents. [HDBU][OAc] was proved to be an efficient catalyst and solvent providing thioether derivatives in good to excellent yields. The ionic liquid could be reused for five times without noticeable loss of activity. The structures of compounds were confirmed by 1H‐, 13C NMR and IR spectroscopy and mass spectral analysis. A series of these pregnenolone derivatives were evaluated for their cytotoxic activity on breast cancer (MDA‐MB‐231, MCF7) cell lines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
