Abstract
AbstractLamotrigine is a sodium channel antagonist used for the treatment of epilepsy. Synthesis of stable isotopically labelled (SIL) [M+7] versions of Lamotrigine (1) and its N‐methylated metabolite (2) are described. The routes to prepare these compounds used [M+5] labelled [13C, 15N4]‐aminoguanidine (obtained from labelled thiourea). The overall yield for the metabolite (2) was 34% from [M+3] labelled [13C, 15N2]‐thiourea. Copyright © 2002 John Wiley & Sons, Ltd.
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