Synthesis of Spirooxindoles: Compounds of Wide Therapeutical Applications

Abstract

Oxindoles and spirooxindoles are important synthetic targets due to their biological activity and applications to pharmaceutical lead discovery. The spirooxindole structure is commonly found in a variety of complex alkaloids and many compounds that possess a spirooxindole moiety exhibit significant biological activity. Herein, we have proposed an easy and efficient access to spirooxindole from an isatin derivative, an aldehyde and a pipecolic ester to get such compounds efficiently and conveniently.