Abstract
A series of 18 new α-β-unsaturated β,δ-disubstituted δ-lactones was synthesized as possible therapeutic agents. The majority of the compounds described contain an aryloxy group in the β-position of the lactone ring, while those naturally occurring in Piper methysticum all contain an alkoxy group in this position. Some of the lactones were hydrogenated by means of palladium-on-charcoal to the corresponding dihydro derivatives. The infrared absorption spectra of most of the synthesized compounds were also studied. A series of 18 new α-β-unsaturated β,δ-disubstituted δ-lactones was synthesized as possible therapeutic agents. The majority of the compounds described contain an aryloxy group in the β-position of the lactone ring, while those naturally occurring in Piper methysticum all contain an alkoxy group in this position. Some of the lactones were hydrogenated by means of palladium-on-charcoal to the corresponding dihydro derivatives. The infrared absorption spectra of most of the synthesized compounds were also studied.
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