Synthesis of some quinazolinone derivatives using magnetic nanoparticles-supported tungstic acid as antimicrobial agents

Abstract

Quinazolinones are appealing materials because of their precious biological effects. In this study 10 new quinazolinone derivatives (4a–4j) were synthesized via an efficient three-component condensation reaction between anthranilic acid, acetic anhydride and different amines. This process was carried out for the first time in the presence of catalytic amount of magnetic nanoparticle supported tungstic acid, under solvent-free condition. The acidic catalyst can be easily reusing by an outward magnetic field after completion the reaction without any uncleanness. Chemical structures of the products were confirmed by spectroscopic methods such as: 1HNMR and 13CNMR, IR and elemental analysis. Antifungal and antibacterial activities were evaluated against different species of microorganisms including gram positive and gram negative bacteria as well as fungi. Broth microdilution method as recommended by clinical and laboratory standard institute was used for this purpose. The results show compounds 4h had the best antibacterial and antifungal activity against the examined bacteria and fungi. Compounds 4a–d and 4f also showed good activity against some species. Synthesis of quinazoline derivatives as antimicrobial agents in the presence of MNP-TA