Abstract
Abstract3‐Amino‐4‐hydroxy‐6‐phenylpyrano[3,2‐c]quinoline‐2,5(6H)‐dione was produced by a smooth reduction of its nitro precursor. Reaction of this 3‐amino‐4‐hydroxypyranoquinoline derivative with different electrophiles, leading to a variety of oxazolo and oxazinopyrano[3,2‐c]quinoline derivatives, was described. The structure of the new products was elucidated via elemental analysis, IR, 1H NMR, 13C NMR, and mass spectra. Also, screening the antitumor activity of new compounds against two human cell lines (HepG‐2 and HCT‐116) was carried out. Some new products showed significant antitumor activities.
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