Synthesis of Some Novel Isoxazoline from Sec 3-Amino Pyridazine Chalcones and Their Antimicrobial Studies

Abstract

Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in the presence of hydroxylamine hydrochloride. Isoxazoline is an important class of nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active compounds have been synthesized using it as an intermediate. Due to this activity, it is found useful in the treatment of anti-fungal, anti-bacterial, anti-cancer, anti-amoebic, and anti-inflammatory agents. The structures of the isoxazoline derivatives were confirmed by spectral analysis. The synthesized isoxazoline shows moderate activity against bacteria and fungus.