Abstract

The synthesis of new 2(3 H)-benzoxazolinonylcarboxamides starting from 2-amino-4,6-dimethylpyridine and 2(3 H)-benzoxazolone which were designed as anti-inflammatory agents is described. These derivatives were synthesised from 2(3 H)-(benzoxazolinon-6-yl)carboxylic acids, which were obtained by Friedel–Crafts acylation of 2(3 H)-benzoxazolone derivatives with oxalyl chloride and acetylchloride in the presence of the AlCl3–DMF complex. The constitution of the products was supported by elemental analysis IR and 1H NMR spectral data.

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