Abstract
This research includes preparing of some substituted 1,2,4-triazoles and 1,3,4thiadiazoles through the reaction of each of phthalimide and cis-1,2,3,6-tetrahydrophthalimide with ethyl bromo acetate in the presence of sodium hydroxide, and absolute ethanol to obtain the esters ethyl phthalimide acetate, then converted these esters to thiosemicarbazide and semicarbazide derivatives through their reaction with thiosemicarbazide and semicarbazide respectively. Furthermore, substituted triazole were prepared through the cyclization of thiosemicarbazide and semicarbazide in alkaline media such as sodium hydroxide solution, also thiadiazole through the treatment of esters, ethyl phthalimide acetate and ethyl cis-1,2,3,6tetrahydrophthalimide acetate with thiosemicarbazide in the presence of a base. The prepared compounds were identified by spectral methods FTIR, 1 H-NMR, 13 C-NMR, and measurements some of its physical properties and some specific reactions, furthermore we were studied the effects of the preparing compounds on some strains of bacteria, Staphylococus aureus,Escherichia Coli, Serrtia, which exhibited antibacterial activity against Escherichia Coli specifically and have no effect on other strains.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.