Synthesis of some new pyrrolyl dipyrazoles and pyrrolyl pyrazolyl isoxazoles and biological evaluation as antioxidants

Abstract

Some new systems of tris-heterocyclic pyrrolyl dipyrazoles (5) and pyrrolyl pyrazolyl isoxazoles (7) were prepared from the Michael acceptor E-1-(4-aryl-1H-pyrazol-3-yl)-3-(1H-pyrrol-2-yl)prop-2-en-1-one (3) using conventional and ultrasonication methods. All compounds were obtained in higher yield and shorter reaction time when using the ultrasound irradiation method compared with the conventional method. The title compounds were assayed for their antioxidant activity. Amongst all the tested compounds, 5c and 7c exhibited pronounced antioxidant activity compared with the standard drug.