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Abstract
A series of arylthioureas ( 1), aromatic aldehyde thiosemicarbazones ( 2) and 5-aryl-2-furfuraldehyde thiosemicarbazones ( 3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles ( 4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.
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