Synthesis of some N-substituted 2- and 3-methyl-4-piperidones

Abstract

1. Convenient methods for the synthesis of 2-methyl- and 1,2-dimethyl-4-piperidones are proposed. 2. Several variants of the synthesis of 1-(1,1-dimethyl-2-propynyl)-2-methyl-4-piperidone were examined. 3. 1-p-Tolylsulfonyl derivatives of 4-piperidones do not undergo the amino-exchange reaction when heated with primary amines in presence of caustic alkalies.