Abstract
Synthesis of Some N-Alkyl and N-Aryl Amides as Potential Central Nervous System-Active Anticonvulsant Agents
Highlights
BackgroundEpilepsy affects about 0.5 to 1% of the world’s population
Convulsion condition is characterized by violent, uncontrolled spasmodic contractions and relaxations of the voluntary muscles
Correlation Equations that are significant at the 0.01 level (2-tailed) were used for prediction of Anticonvulsant Activity The acidity of all the prepared carboxamides were within the predicted property like ionization constant (pKa) working range (13.50 to 15.50)
Summary
Epilepsy affects about 0.5 to 1% of the world’s population. The perfect anti-epileptic drug is as yet unavailable. A carefully balance between toxicity site of most available anti-epileptic agent and their seizure activity are mostly done before uses. New and safe anticonvulsant drugs are urgently needed. Most drugs in current usage have developed based on optimization of lead compounds, either isolated from the screening of natural products, or modified from hormone or transmitter whose activity is being studied
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