Abstract
The activity of an antispasmodic of the atropine type appears to be related to the rigidity of the nitrogen-containing moiety. Hexamine contains a very rigid ring system, and it would seem that hexamine would furnish a promising starting point in the synthesis of a good antispasmodic. Some hexamine derivatives were synthesized by reacting the appropriate halomethyl amide or ketone with an excess of hexamine in refluxing chloroform. Preliminary pharmacological evaluation indicates that one of the hexamine derivatives possesses good antispasmodic activity.
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